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Miaderm Radiation Relief
Prevention of Radiation Dermatitis & Advanced Healing For Skin Damage Resulting From Radiation Therapy
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Heal and Soothe Skin Problems from Radiation |
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CALENDULA (>4%) |
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HYALURONATE (>4%) |
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ALOE VERA (>4%) |
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In a
prospective, randomized study of 254 radiation patients, topical, application of 4% calendula ointment resulted in far
fewer occurrences of Grade 2 of higher clematitis than occurred in the group using Biafine (trilamine). Calendula users also experienced less radiation induced pain and fewer breaks in treatment.
(Pommier P.et al. J
Clinical Oncol 2004; 22:447-1453) |
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In a randomized double-blind placebo-controlled study of 134 radiation patients, 0.2% hyaluronate
cream was shown to significantly reduce the
incidence of high-grade skin reactions, delay
their onset & reduce their severity. The study also noted hyaluonate's association with faster
skin recovery times.
(Ligouri
V. et al, Radioth Oncol. 1997; 2:155-161) |
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In a prospective, randomized and blinded study, patients who applied aloe vera after applying a mild soap solution experienced initial skin irritation two weeks later than those who used the soap but not the aloe.
The study noted that this finding suggests aloe vera may have a proactive effect.
(Olsen DL, et al.
Oncol Nurs forum.
2001; 28:543-247) |
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One of the most uncomfortable side effects of radiation therapy is the
skin reaction in the area being treated. Similar to a sunburn the skin may react with a mild to moderate pink color, or redness
accompanied by itching, burning, soreness, and peeling. The effects of radiation on the skin are the most common side effects of
radiation treatment, with up to 95% of patients experiencing an adverse skin reaction. One of the most significant problems
associated with radiation dermatitis (burns) is that it can force interruptions in treatment, which have been proven to increase the
risk of the cancer recurring.
Miaderm was developed by radiation oncologists specifically to minimize patients' skin-related side effects and ensure the
effectiveness of their treatment. The goal was to create a lotion using an evidence based, scientific approach, with ingredients
clinically proven to help:
- reduce radiations effects on the skin
- soothe and restore radiation-damaged skin
- reduce or eliminate breaks in radiation treatment
Miaderm Radiation Relief lotion is a water-based lotion formulated with ingredients that are supported by scientific studies. The key
ingredients of calendula, hyaluronate (hyaluronic acid), and aloe vera have been clinically proven to be effective in phase III
prospective randomized trials published in peer reviewed scientific journals. The sole purpose of Miaderm is to help decrease the skin
effects that patients experience in being treated with radiation therapy.
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Calendula (1) when compared to Biafine (trolamine)
was shown to decrease the incidence of grade 2 or higher
radiation dermatitis as well as reduce the incidence of
treatment breaks. The study was a phase III
prospective clinical trial published in the Journal of
Clinical Oncology. A treatment break occurs when the skin
is so damaged that radiation has to stop temporarily to allow
for wound healing. Hyaluronate (2) when compared to a placebo cream was also
shown to reduce the incidence of high grade radiation skin reactions, delay their onset, and reduce their severity. Earlier
recovery was also seen in this phase three prospective trial, published in the journal Radiotherapy Oncology. There have been many
studies looking at aloe vera effectiveness in treating and preventing radiation dermatitis. A phase III clinical study
published in Oncology Nursing Forum showed that compared to mild soap alone, aloe vera (3) can delay the occurrence of radiation
dermatitis. Other studies looking at aloe vera and radiation skin effects have not shown a proven benefit. To our knowledge Miaderm
Radiation Relief is the only radiation therapy lotion formulated with greater than 4% concentrations of calendula, hyaluronate, and
aloe vera.
To get the full benefit of Miaderm Radiation Relief should be started at the initiation of radiation therapy and continued for two
weeks following the completion of treatment. Miaderm Radiation Relief lotion is unconditionally guaranteed.
(1) Pommier P, Gomez F, Sunyach MP, et al: Phase III randomized trial of calendula officinalis compared with
trolamine for the prevention of acute dermatitis during irradiation for breast cancer. Journal of Clinical Oncology
22:1447-1453, 2004
(2) Liguori V, Guillemin C, Pesce GF, et al: Double-blind, randomized clinical study comparing hyaluronic acid cream to
placebo in patients treated with radiotherapy. Radiotherapy Oncology 42:155–161, 1997
(3) Olsen DL, Raub W, Bradley C, et al: The effect of aloe vera gel versus mild soap alone in preventing skin reactions in
patients undergoing radiation therapy. Oncology Nursing Forum 28:543-547, 2001
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